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Signaling Pathways from the Endoplasmic Reticulum and Their Roles in Disease

1 Jul 2013

Abstract excerpt

The endoplasmic reticulum (ER) is an organelle in which newly synthesized secretory and transmembrane proteins are assembled and folded into their correct tertiary structures. However, many of these ER proteins are misfolded as a result of various stimuli and gene mutations. The accumulation of misfolded proteins disrupts the function of the ER and induces ER stress. Eukaryotic cells possess a highly conserved...

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PMID: 24705207
DOI: 10.3390/genes4030306

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