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PERK-Olating Through Cancer: A Brew of Cellular Decisions

8 Feb 2025

Abstract excerpt

The type I protein kinase PERK is an endoplasmic reticulum (ER) transmembrane protein that plays a multifaceted role in cancer development and progression, influencing tumor growth, metastasis, and cellular stress responses. The activation of PERK represents one of the three signaling pathways induced during the unfolded protein response (UPR), which is triggered, in particular, in tumor cells that constitutively...

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PMID: 40001551
DOI: 10.3390/biom15020248

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