Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endoplasmic reticulum proteostasis: a key checkpoint in cancer

18 Nov 2016

Abstract excerpt

The unfolded protein response (UPR) is an intracellular signaling network largely controlled by three endoplasmic reticulum (ER) transmembrane proteins, inositol-requiring enzyme 1α, PRK-like ER kinase, and activating transcription factor 6, that monitor the protein-folding status of the ER and initiate corrective measures to maintain ER homeostasis. Hypoxia, nutrient deprivation, proteasome dysfunction,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27856431
DOI: 10.1152/ajpcell.00266.2016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endoplasmic reticulum proteostasis: a key checkpoint in cancerPMID 27856431Read ↗

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistanceSemantic proximity Read ↗

The “Yin and Yang” of Unfolded Protein Response in Cancer and Immunogenic Cell DeathSemantic proximity Read ↗

Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell FateSemantic proximity Read ↗

How the Unfolded Protein Response Is a Boon for Tumors and a Bane for the Immune SystemSemantic proximity Read ↗

Targeting the hallmarks of cancer with therapy-induced endoplasmic reticulum (ER) stressSemantic proximity Read ↗

The Unfolded Protein Response: A Novel Therapeutic Target in Acute LeukemiasSemantic proximity Read ↗

Endoplasmic Reticulum Stress and CancerSemantic proximity Read ↗

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in CarcinogenesisSemantic proximity Read ↗

Integrated Endoplasmic Reticulum Stress Responses in CancerSemantic proximity Read ↗

PERK-Olating Through Cancer: A Brew of Cellular DecisionsSemantic proximity Read ↗

Understanding ER homeostasis and the UPR to enhance treatment efficacy of acute myeloid leukemiaSemantic proximity Read ↗

Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.