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Naturally occurring mutations in G protein-coupled receptors associated with obesity and type 2 diabetes mellitus.

Pharmacology & therapeutics - 1 Jun 2022

Liu Ting, Ji Ren-Lei, Tao Ya-Xiong

Abstract excerpt

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors involved in the regulation of almost all known physiological processes. Dysfunctions of GPCR-mediated signaling have been shown to cause various diseases. The prevalence of obesity and type 2 diabetes mellitus (T2DM), two strongly associated disorders, is increasing worldwide, with tremendous economical and health burden. New safer...

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Diabetes Mellitus, Type 2
Glucagon-Like Peptide-1 Receptor
Mutation
Obesity
Receptors, G-Protein-Coupled

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34822948
DOI: 10.1016/j.pharmthera.2021.108044

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