Article
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity.
Science (New York, N.Y.) - 2 Jul 2021
Akbari Parsa, Gilani Ankit, Sosina Olukayode, Kosmicki Jack A, Khrimian Lori, Fang Yi-Ya, Persaud Trikaldarshi, Garcia Victor, Sun Dylan, Li Alexander, Mbatchou Joelle, Locke Adam E, Benner Christian, Verweij Niek, Lin Nan, Hossain Sakib, Agostinucci Kevin, Pascale Jonathan V, Dirice Ercument, Dunn Michael, Kraus William E, Shah Svati H, Chen Yii-Der I, Rotter Jerome I, Rader Daniel J, Melander Olle, Still Christopher D, Mirshahi Tooraj, Carey David J, Berumen-Campos Jaime, Kuri-Morales Pablo, Alegre-Díaz Jesus, Torres Jason M, Emberson Jonathan R, Collins Rory, Balasubramanian Suganthi, Hawes Alicia, Jones Marcus, Zambrowicz Brian, Murphy Andrew J, Paulding Charles, Coppola Giovanni, Overton John D, Reid Jeffrey G, Shuldiner Alan R, Cantor Michael, Kang Hyun M, Abecasis Goncalo R, Karalis Katia, Economides Aris N, Marchini Jonathan, Yancopoulos George D, Sleeman Mark W, Altarejos Judith, Della Gatta Giusy, Tapia-Conyer Roberto, Schwartzman Michal L, Baras Aris, Ferreira Manuel A R, Lotta Luca A
Abstract excerpt
Large-scale human exome sequencing can identify rare protein-coding variants with a large impact on complex traits such as body adiposity. We sequenced the exomes of 645,626 individuals from the United Kingdom, the United States, and Mexico and estimated associations of rare coding variants with body mass index (BMI). We identified 16 genes with an exome-wide significant association with BMI, including those...
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