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Central regulation of feeding and body weight by ciliary GPR75

13 Aug 2024

Abstract excerpt

Variants of the G protein-coupled receptor 75 (GPR75) are associated with a lower BMI in large-scale human exome-sequencing studies. However, how GPR75 regulates body weight remains poorly understood. Using random germline mutagenesis in mice, we identified a missense allele (Thinner) of Gpr75 that resulted in a lean phenotype and verified the decreased body weight and fat weight in Gpr75-knockout (Gpr75-/-)...

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PMID: 39137039
DOI: 10.1172/jci182121

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