Article

G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis

2022-05-28

Abstract excerpt

Human genetics has been instrumental in identification of genetic variants linked to type 2 diabetes (T2D). Recently a rare, putative loss-of-function mutation in the orphan G-protein coupled receptor 151 ( GPR151 ) was found to be associated with lower odds ratio for T2D, but the mechanism behind this association has remained elusive. Here for the first time we show that Gpr151 is a fasting- and glucagon-respon...

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Literature Corpus work: 8560f528-66b7-5472-8b63-9b0110b13216
DOI: 10.1101/2022.05.25.493489

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