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Article

Identification and characterization of human GDF15 knockouts

2024-03-18

Abstract excerpt

Growth differentiation factor 15 (GDF15) is a secreted protein that regulates food intake, body weight, and stress responses in pre-clinical models 1 . The physiological function of GDF15 in humans remains unclear. Pharmacologically, GDF15 agonism in humans caused nausea without accompanying weight loss 2 , and the effect of GDF15 antagonism is being tested in clinical trials to treat cachexia and anorexia. Human...

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Literature Corpus work
ae572bd5-2a4b-5cc1-a63a-ccb75484f1f2
DOI
10.1101/2024.03.14.24303793
Open publication

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Identification and characterization of human GDF15 knockoutsDOI 10.1101/2024.03.14.24303793
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