Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.

doi:10.1038/nature10798

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Article

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.

Nature - 19 Feb 2012

Ichimura Atsuhiko, Hirasawa Akira, Poulain-Godefroy Odile, Bonnefond Amélie, Hara Takafumi, Yengo Loïc, Kimura Ikuo, Leloire Audrey, Liu Ning, Iida Keiko, Choquet Hélène, Besnard Philippe, Lecoeur Cécile, Vivequin Sidonie, Ayukawa Kumiko, Takeuchi Masato, Ozawa Kentaro, Tauber Maithé, Maffeis Claudio, Morandi Anita, Buzzetti Raffaella, Elliott Paul, Pouta Anneli, Jarvelin Marjo-Riitta, Körner Antje, Kiess Wieland, Pigeyre Marie, Caiazzo Roberto, Van Hul Wim, Van Gaal Luc, Horber Fritz, Balkau Beverley, Lévy-Marchal Claire, Rouskas Konstantinos, Kouvatsi Anastasia, Hebebrand Johannes, Hinney Anke, Scherag Andre, Pattou François, Meyre David, Koshimizu Taka-aki, Wolowczuk Isabelle, Tsujimoto Gozoh, Froguel Philippe

Abstract excerpt

Free fatty acids provide an important energy source as nutrients, and act as signalling molecules in various cellular processes. Several G-protein-coupled receptors have been identified as free-fatty-acid receptors important in physiology as well as in several diseases. GPR120 (also known as O3FAR1) functions as a receptor for unsaturated long-chain free fatty acids and has a critical role in various...

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PMID: 22343897
DOI: 10.1038/nature10798

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