Article

Identification and molecular characterization of missense mutations in orphan GPCR GPR61 occurring in severe obesity

2024-10-22

Abstract excerpt

Obesity is a disease defined as “abnormal or excessive fat accumulation that presents a health risk, with a body mass index (BMI) over 30” (World Health Organization). Signalling mediated by hypothalamus-expressed membrane proteins from the GPCR family regulates food intake and metabolism. The orphan GPCR GPR61 was linked to regulation of metabolism and, here, we identify 34 mutations in the GPR61 gene which are p...

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Literature Corpus work: b0454211-2f38-51ff-87d9-f675070701ce
DOI: 10.1101/2024.10.21.24315834

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