Article
mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts.
Gene - 1 May 2016
Caruso Vanni, Sreedharan Smitha, Carlini Valeria P, Jacobsson Josefin A, Haitina Tatjana, Hammer Joanna, Stephansson Olga, Crona Filip, Sommer Wolfgang H, Risérus Ulf, Lannfelt Lars, Marcus Claude, Heilig Markus, de Barioglio Susana R, Fredriksson Robert, Schiöth Helgi B
Abstract excerpt
G protein-coupled receptors (GPCRs) are a class of integral membrane proteins mediating intercellular interactions of fundamental physiological importance for survival including regulation of food intake, blood pressure, and hormonal sensing signaling, among other roles. Homeostatic alterations in the physiological status of GPCRs are often associated with underlying causes of disease, and to date, several orphan...
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