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G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis

1 Dec 2022

Abstract excerpt

Human genetics has been instrumental in identification of genetic variants linked to type 2 diabetes. Recently a rare, putative loss-of-function mutation in the orphan G-protein coupled receptor 151 (GPR151) was found to be associated with lower odds ratio for type 2 diabetes, but the mechanism behind this association has remained elusive. Here we show that Gpr151 is a fasting- and glucagon-responsive hepatic...

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PMID: 36456565
DOI: 10.1038/s41467-022-35069-9

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