Article

Increased cortical volume without increased neuron number in heterozygous <i>Chd8</i> mutant mouse cortex

2021-01-12

Abstract excerpt

De novo mutations in the chromatin-remodeling factor CHD8 (Chromodomain-Helicase DNA-binding protein 8) have emerged as a key genetic risk factor for Autism Spectrum Disorder (ASD) and, more generally, neurodevelopmental disorders. Individuals with heterozygous mutations in CHD8 typically present hallmarks of ASD with comorbid cognitive disability and macrocephaly. Knockdown or haploinsufficiency of Chd8 in ani...

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Literature Corpus work: b81583c1-b4e2-57c1-a193-b45e424542d9
DOI: 10.1101/2021.01.11.426290

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