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Article

Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors.

Cell reports - 23 Feb 2021

Kweon Hanseul, Jung Won Beom, Im Geun Ho, Ryoo Jia, Lee Joon-Hyuk, Do Hogyeong, Choi Yeonsoo, Song You-Hyang, Jung Hwajin, Park Haram, Qiu Lily R, Ellegood Jacob, Shim Hyun-Ji, Yang Esther, Kim Hyun, Lerch Jason P, Lee Seung-Hee, Chung Won-Suk, Kim Daesoo, Kim Seong-Gi, Kim Eunjoon

Abstract excerpt

CHD8 (chromodomain helicase DNA-binding protein 8) is a chromatin remodeler associated with autism spectrum disorders. Homozygous Chd8 deletion in mice leads to embryonic lethality, making it difficult to assess whether CHD8 regulates brain development and whether CHD8 haploinsufficiency-related macrocephaly reflects normal CHD8 functions. Here, we report that homozygous conditional knockout of Chd8 restricted to...

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Identifiers

PMID: 33626347
DOI: 10.1016/j.celrep.2021.108780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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