Article
Pressure Points: Endothelial Responses to Shear Stress and Pressure in Health and Pulmonary Arterial Hypertension
2025-08-02
Abstract excerpt
Background: Hemodynamic forces exert a profound influence on endothelial signaling and, when abnormal, contribute centrally to human vascular disease. Pulmonary arterial hypertension (PAH) is characterized by both hemodynamic derangement and pulmonary arterial endothelial cell (PAEC) dysfunction. Despite importance in disease initiation and progression, the combined effects of shear and pressure forces on PAEC bio...
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Identifiers and source
- Literature Corpus work
- b8016d4d-865d-5fd1-99ad-777706d7e349
- DOI
- 10.1101/2025.07.28.666693