Adrenomedullin-RAMP2 enhances endothelial cell homeostasis synergically with shear stress

Abstract excerpt

Analysis of pulmonary vascular dysfunction in various lung pathologies remains challenging due to the lack of functional ex vivo models. Paracrine signaling in the lung plays a critical role in regulating endothelial maturation and vascular homeostasis. Previously, we employed single-cell RNA-sequencing (scRNAseq) to systematically map ligand-receptor (L/R) interactions within the lung vascular niche. However, th...

Topics

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• Aorta
• Atherosclerosis
• Behcet Syndrome
• Case-Control Studies
• Cell Communication
• COVID-19 Clinical Research Studies
• Phenotype
• Single-Cell Gene Expression Analysis

Identifiers and source

Literature Corpus work

cdd5d430-0479-5cdb-9956-346dcd09da3f

DOI

10.1101/2025.09.21.677608