Matrix stiffness shifts the endothelial shear stress set point for angiogenic activation

Abstract excerpt

<h4>Aims</h4> Endothelial cells (ECs) are simultaneously exposed to wall shear stress (SS) from blood flow and substrate stiffness (SFN) from the extracellular matrix, yet how these cues are integrated to shape endothelial behavior remains incompletely understood. We applied an unbiased transcriptomics strategy to define how SS and substrate SFN jointly encode endothelial state transitions and determine angiogeni...

Topics

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• Base Sequence
• Biomechanical Phenomena
• Cells, Cultured
• DNA Primers
• Endothelium, Vascular
• Gene Expression Profiling
• Molecular Sequence Data
• Nucleic Acid Hybridization

Identifiers and source

Literature Corpus work

e4e113db-22ed-58b9-93b0-f0e389703e91

DOI

10.64898/2026.07.22.740002