Article
Biomechanical activation of vascular endothelium as a determinant of its functional phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2001
Garcia-Cardeña G, Comander J, Anderson K R, Blackman B R, Gimbrone M A
Abstract excerpt
One of the striking features of vascular endothelium, the single-cell-thick lining of the cardiovascular system, is its phenotypic plasticity. Various pathophysiologic factors, such as cytokines, growth factors, hormones, and metabolic products, can modulate its functional phenotype in health and disease. In addition to these humoral stimuli, endothelial cells respond to their biomechanical environment, although...
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