Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

doi:10.1158/2159-8290.CD-15-0235

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Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

Cancer discovery - 1 Nov 2015

Seashore-Ludlow Brinton, Rees Matthew G, Cheah Jaime H, Cokol Murat, Price Edmund V, Coletti Matthew E, Jones Victor, Bodycombe Nicole E, Soule Christian K, Gould Joshua, Alexander Benjamin, Li Ava, Montgomery Philip, Wawer Mathias J, Kuru Nurdan, Kotz Joanne D, Hon C Suk-Yee, Munoz Benito, Liefeld Ted, Dančík Vlado, Bittker Joshua A, Palmer Michelle, Bradner James E, Shamji Alykhan F, Clemons Paul A, Schreiber Stuart L

Abstract excerpt

UNLABELLED: Identifying genetic alterations that prime a cancer cell to respond to a particular therapeutic agent can facilitate the development of precision cancer medicines. Cancer cell-line (CCL) profiling of small-molecule sensitivity has emerged as an unbiased method to assess the relationships between genetic or cellular features of CCLs and small-molecule response. Here, we developed annotated cluster...

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PMID: 26482930
DOI: 10.1158/2159-8290.CD-15-0235
PMCID: PMC4631646

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