Article

CancerFoundation: A single-cell RNA sequencing foundation model to decipher drug resistance in cancer

2024-11-02

Abstract excerpt

We present CancerFoundation, a novel single-cell RNA-seq foundation model (scFM) trained exclusively on malignant cells. Despite being trained on only one million total cells, a fraction of the data used by existing models, CancerFoundation outperforms other scFMs in key tasks such as zero-shot batch integration and drug response prediction. During training, we employ tissue and technologyaware oversampling and do...

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Literature Corpus work: 7c7cebf2-86ae-56ac-8f7b-d7a97e24a74d
DOI: 10.1101/2024.11.01.621087

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