Article

Disruption of Striatal Intrinsic Ignition in Huntington’s Disease: an In-Silico Perturbational Approach to Emulate Disease Progression and Recovery

2025-12-10

Abstract excerpt

Huntington’s disease (HD) is a neurodegenerative disorder caused by a single gene that severely affects motor, cognitive, and behavioral functions and is ultimately fatal. While disruptions in the structural integrity of the striatum are well documented, less is known about how the underlying functional impairments relate to the disease. We developed a large-scale modeling framework based on intrinsic ignition to...

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Literature Corpus work: b7d6df33-b1fb-5e90-8b88-4872d81070f3
DOI: 10.64898/2025.12.08.691368

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