Article

Network Dysconnection of Striatum and Default Mode Network Underpins Temporal Dynamics of Depression in Premanifest Huntington’s Disease

2025-08-06

Abstract excerpt

<h4>Background and objectives</h4> Depression emerges years before motor signs in Huntington”s disease gene expansion carriers (HDGECs), yet how directional connectivity patterns evolve over time and relate to depression trajectories remains unknown. We hypothesized HDGECs with depression history would show accelerated grey matter atrophy and disinhibition of striatal-to-default mode network connections over time...

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Literature Corpus work: df4e3ba4-e0d6-5a98-a001-bdee10012d63
DOI: 10.1101/2025.08.04.668558

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