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Article

Local synchronicity in dopamine-rich caudate nucleus influences Huntington's disease motor phenotype.

Brain : a journal of neurology - 1 Aug 2023

Kasper Jan, Eickhoff Simon B, Caspers Svenja, Peter Jessica, Dogan Imis, Wolf Robert Christian, Reetz Kathrin, Dukart Juergen, Orth Michael

Abstract excerpt

Structural grey and white matter changes precede the manifestation of clinical signs of Huntington's disease by many years. Conversion to clinically manifest disease therefore likely reflects not merely atrophy but a more widespread breakdown of brain function. Here, we investigated the structure-function relationship close to and after clinical onset, in important regional brain hubs, particularly caudate...

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PMID: 36795496
DOI: 10.1093/brain/awad043

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