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Article

Striatal network modeling in Huntington's Disease.

PLoS computational biology - 1 Apr 2020

Ponzi Adam, Barton Scott J, Bunner Kendra D, Rangel-Barajas Claudia, Zhang Emily S, Miller Benjamin R, Rebec George V, Kozloski James

Abstract excerpt

Medium spiny neurons (MSNs) comprise over 90% of cells in the striatum. In vivo MSNs display coherent burst firing cell assembly activity patterns, even though isolated MSNs do not burst fire intrinsically. This activity is important for the learning and execution of action sequences and is characteristically dysregulated in Huntington's Disease (HD). However, how dysregulation is caused by the various neural...

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Identifiers

PMID: 32302302
DOI: 10.1371/journal.pcbi.1007648
PMCID: PMC7197869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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