Article

Depression reduces structurally informed network flexibility in premanifest Huntington’s disease

2025-09-28

Abstract excerpt

1 <h4>Background and objectives</h4> The extent to which structural connectivity constrains effective connectivity in both depression and neurodegenerative contexts remains poorly understood. In particular, the relationship between structural connectivity aberrations and effective dysconnectivity associated with depression in Huntingtin’s disease remains uncharacterized. Here, we applied a novel procedure that im...

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Literature Corpus work: d8762129-007f-564e-827b-3c9cf5a0d021
DOI: 10.1101/2025.09.25.678149

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