Article

Imbalanced basal ganglia connectivity is associated with motor deficits and apathy in Huntington’s disease

2021-07-06

Abstract excerpt

The gating of movement depends on activity within the cortico-striato-thalamic loops. Within these loops, emerging from the cells of the striatum, run two opponent pathways – the direct and indirect basal ganglia pathway. Both are complex and polysynaptic but the overall effect of activity within these pathways is thought to encourage and inhibit movement respectively. In Huntington’s disease (HD), the preferentia...

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Identifiers and source

Literature Corpus work: 2142474b-f64d-565f-97a6-d6569afed3a7
DOI: 10.1101/2021.07.01.21259448

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