Article

A genome wide dosage suppressor network reveals genetic robustness and a novel mechanism for Huntingtons disease

2013-11-12

Abstract excerpt

Mutational robustness is the extent to which an organism has evolved to withstand the effects of deleterious mutations. We explored the extent of mutational robustness in the budding yeast by genome wide dosage suppressor analysis of 53 conditional lethal mutations in cell division cycle and RNA synthesis related genes, revealing 660 suppressor interactions of which 642 are novel. This collection has several disti...

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Literature Corpus work: b7d62805-78e9-57fd-8502-5fad223d3b58
DOI: 10.1101/000265

Open publication

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