Global analysis of suppressor mutations that rescue human genetic defects.

Abstract excerpt

BACKGROUND: Genetic suppression occurs when the deleterious effects of a primary "query" mutation, such as a disease-causing mutation, are rescued by a suppressor mutation elsewhere in the genome. METHODS: To capture existing knowledge on suppression relationships between human genes, we examined 2,400 published papers for potential interactions identified through either genetic modification of cultured human...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genome, Human
• Share to Human Genetics
• Share to Models, Biological