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Article

Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Science (New York, N.Y.) - 17 Oct 2008

Roguev Assen, Bandyopadhyay Sourav, Zofall Martin, Zhang Ke, Fischer Tamas, Collins Sean R, Qu Hongjing, Shales Michael, Park Han-Oh, Hayles Jacqueline, Hoe Kwang-Lae, Kim Dong-Uk, Ideker Trey, Grewal Shiv I, Weissman Jonathan S, Krogan Nevan J

Abstract excerpt

An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe, by systematically measuring the phenotypes associated with pairs of mutations. This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcripti...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18818364
DOI: 10.1126/science.1162609
PMCID: PMC2753251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18818364-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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