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Article

A genome wide dosage suppressor network reveals genomic robustness.

Nucleic acids research - 9 Jan 2017

Patra Biranchi, Kon Yoshiko, Yadav Gitanjali, Sevold Anthony W, Frumkin Jesse P, Vallabhajosyula Ravishankar R, Hintze Arend, Østman Bjørn, Schossau Jory, Bhan Ashish, Marzolf Bruz, Tamashiro Jenna K, Kaur Amardeep, Baliga Nitin S, Grayhack Elizabeth J, Adami Christoph, Galas David J, Raval Alpan, Phizicky Eric M, Ray Animesh

Abstract excerpt

Genomic robustness is the extent to which an organism has evolved to withstand the effects of deleterious mutations. We explored the extent of genomic robustness in budding yeast by genome wide dosage suppressor analysis of 53 conditional lethal mutations in cell division cycle and RNA synthesis related genes, revealing 660 suppressor interactions of which 642 are novel. This collection has several distinctive...

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Identifiers

PMID: 27899637
DOI: 10.1093/nar/gkw1148
PMCID: PMC5224485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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