Article

<i>In Silico</i> Improvement of Highly Protective Anti-Malarial Antibodies

2022-04-09

Abstract excerpt

<h4>SUMMARY</h4> Antibody CIS43 binds Plasmodium falciparum circumsporozoite protein (PfCSP) and protects against malaria, as recently demonstrated clinically. To improve the efficacy of CIS43, we developed an in silico pipeline to optimize the interaction energy of CIS43 to its junctional epitope (peptide 21: PfCSP residues 101-115). Starting from two improved CIS43 variants, recently elicited from a CIS43-ger...

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Literature Corpus work: b7d5ca84-baba-5600-9ebd-8ab9856bfd4a
DOI: 10.1101/2022.04.08.487687

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