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Highly protective antimalarial antibodies via precision library generation and yeast display screening

24 May 2022

Abstract excerpt

The monoclonal antibody CIS43 targets the Plasmodium falciparum circumsporozoite protein (PfCSP) and prevents malaria infection in humans for up to 9 mo following a single intravenous administration. To enhance the potency and clinical utility of CIS43, we used iterative site-saturation mutagenesis and DNA shuffling to screen precise gene-variant yeast display libraries for improved PfCSP antigen recognition. We...

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PMID: 35736810
DOI: 10.1084/jem.20220323

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