Article

Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infection

2022-09-21

Abstract excerpt

<h4>Summary</h4> The generation of high-quality antibody responses to PfCSP, the primary surface antigen of Plasmodium falciparum sporozoites, is paramount to the development of an effective malaria vaccine. Here we present an in-depth structural and functional analysis of a panel of potent antibodies encoded by the IGHV3-33 germline gene, which is among the most prevalent and potent antibody families induced i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 74b6c235-5715-5584-88fa-a0058d164615
DOI: 10.1101/2022.09.20.508747

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infectionDOI 10.1101/2022.09.20.508747Read

Evolution of protective human antibodies against <i>Plasmodium falciparum</i> circumsporozoite protein repeat motifsSemantic proximity Read

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody ClonotypeSemantic proximity Read

Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparumSemantic proximity Read

Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotypeSemantic proximity Read

Structural and biophysical correlation of anti-NANP antibodies with <i>in vivo</i> protection against <i>P. falciparum</i>Semantic proximity Read

Structural characterization of MAM01 and other cost-effective engineered monoclonal antibodies for malaria preventionSemantic proximity Read

Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.Semantic proximity Read

Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccineSemantic proximity Read

Structural elucidation of full-length Pfs48/45 in complex with potent mAbs isolated from a naturally exposed individualSemantic proximity Read

Highly protective antimalarial antibodies via precision library generation and yeast display screeningSemantic proximity Read

<i>In Silico</i> Improvement of Highly Protective Anti-Malarial AntibodiesSemantic proximity Read

Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite ProteinSemantic proximity Read