Article

Affinity maturation of cross-reactive CR3022 antibody against the receptor binding domain of SARS-CoV-2 via in silico site-directed mutagenesis

2021-04-02

Abstract excerpt

<title>Abstract</title> <p><bold>Introduction:</bold> Computational antibody engineering, affinity maturation, and screening greatly aid in vaccine and therapeutic antibody development by increasing the speed and accuracy of predictions. This study presents a protocol for designing affinity enhancing mutants of antibodies through <italic>in silico</italic> mutagenesis. A SARS-CoV-2 cross-reactive neutralizing ant...

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Literature Corpus work: f8faf824-8f0b-57bf-8684-f27e9917e8a1
DOI: 10.21203/rs.3.rs-92745/v2

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