Article

Mapping the endothelial O-GlcNAcome uncovers CCAR1 as a regulator of senescence

2026-02-14

Abstract excerpt

O-GlcNAcylation, the reversible addition of O-linked N-acetylglucosamine (O-GlcNAc) to serine and threonine residues, is a dynamic posttranslational modification that integrates nutrient and stress signals to fine-tune protein function and maintain cellular homeostasis. Although dysregulation of O-GlcNAc signaling is associated with age-related pathologies, its role in physiological aging remains unclear. Here we...

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Literature Corpus work: b7cd9ac3-ea1a-563b-96ee-424772d66d38
DOI: 10.64898/2026.02.12.705616

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