Article

Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis

2025-08-19

Abstract excerpt

Endothelial cells (ECs) are critical regulators of vascular function and exhibit specialized, organ-specific roles across tissues. During aging, these cells become dysfunctional, resulting in increased susceptibility to cardiovascular disease and its associated mortality. While single-cell transcriptomics studies have revealed extensive endothelial heterogeneity across tissues and conditions, a comprehensive atlas...

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Literature Corpus work: 14fa5026-130f-574f-8252-0009341fb641
DOI: 10.1101/2025.08.18.669055

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