Article

Multi-omics integrative approach of senescent endothelial cells and derived extracellular vesicles in a replicative senescence model

2025-11-28

Abstract excerpt

Aging is a major unmodifiable risk factor for cardiovascular disease (CVD). Replicative endothelial senescence (RES), characterized by permanent cell-cycle arrest and a senescence-associated secretory phenotype (SASP), is a hallmark of vascular aging. However, the molecular mechanisms underlying RES, particularly the role of extracellular vesicles (EVs), remain poorly understood. To this aim, an integrated multi-o...

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Literature Corpus work: 9d791477-d4dc-5a71-87ea-0db4c4fcdf99
DOI: 10.1101/2025.11.25.690417

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