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Hyperglycemia Promotes Endothelial Cell Senescence through AQR/PLAU Signaling Axis

7 Mar 2022

Abstract excerpt

Hyperglycemia is reported to accelerate endothelial cell senescence that contributes to diabetic complications. The underlying mechanism, however, remains elusive. We previously demonstrated AQR as a susceptibility gene for type 2 diabetes mellitus (T2DM) and showed that it was increased in multiple tissues in models with T2DM or metabolic syndrome. This study aimed to investigate the role of AQR in...

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PMID: 35270021
DOI: 10.3390/ijms23052879

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