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Article

Long term high glucose exposure induces premature senescence in retinal endothelial cells

26 Aug 2022

Abstract excerpt

Purpose: Features of cellular senescence have been described in diabetic retinal vasculature. The aim of this study was to investigate how the high glucose microenvironment impacts on the senescence program of retinal endothelial cells. Methods: Human retinal microvascular endothelial cells were cultured under control and high glucose conditions of 5 mM and 25 mM D-glucose, respectively. Isomeric l-glucose was...

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PMID: 36091370
DOI: 10.3389/fphys.2022.929118

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