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Article

The hexosamine signaling pathway: deciphering the "O-GlcNAc code".

Science's STKE : signal transduction knowledge environment - 29 Nov 2005

Love Dona C, Hanover John A

Abstract excerpt

A dynamic cycle of addition and removal of O-linked N-acetylglucosamine (O-GlcNAc) at serine and threonine residues is emerging as a key regulator of nuclear and cytoplasmic protein activity. Like phosphorylation, protein O-GlcNAcylation dramatically alters the posttranslational fate and function of target proteins. Indeed, O-GlcNAcylation may compete with phosphorylation for certain Ser/Thr target sites. Like...

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Identifiers

PMID: 16317114
DOI: 10.1126/stke.3122005re13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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