Article

KW-2449 and VPA exert therapeutic effects on human neurons and cerebral organoids derived from MECP2-null hESCs

2022-07-21

Abstract excerpt

<title>Abstract</title> <p>Background Rett syndrome (RTT), mainly caused by mutations in methyl-CpG binding protein 2 (MECP2), is one of the most prevalent neurodevelopmental disorders in girls. However, the underlying mechanism of MECP2 remains largely unknown and currently there is no effective treatments available for RTT. Methods We generated MECP2-KO human embryonic stem cells (hESCs), and differentiated t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b7a51ca7-525f-58b7-b4e4-ee0ea60d98c5
DOI: 10.21203/rs.3.rs-1840453/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

KW-2449 and VPA exert therapeutic effects on human neurons and cerebral organoids derived from MECP2-null hESCsDOI 10.21203/rs.3.rs-1840453/v1Read

Molecular and Functional Dysregulations in Novel, Rett Syndrome Patient-Derived Cerebral OrganoidsSemantic proximity Read

Modeling Rett Syndrome with Human Pluripotent Stem Cells: Mechanistic Outcomes and Future Clinical Perspectives.Semantic proximity Read

MECP2T203M mutation disrupts neurogenesis in human cerebral organoids by altering chromatin dynamics and transcriptional regulation.Semantic proximity Read

Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids.Semantic proximity Read

Involvement of extracellular vesicle microRNA clusters in developing healthy and Rett syndrome brain organoids.Semantic proximity Read

Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cerebral organoidsSemantic proximity Read

Rett syndrome from bench to bedside: recent advancesSemantic proximity Read

MeCP2 dysregulation inhibits mitophagy and impairs neural development in cortical organoids.Semantic proximity Read

Transcriptome Analysis of Brain Tissues in a MeCP2-Null Rat Model of Rett SyndromeSemantic proximity Read

Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids.Semantic proximity Read

Multiplex Epigenome Editing of <i>MECP2</i> to Rescue Rett Syndrome NeuronsSemantic proximity Read

WWOX deficiency impairs neurogenesis and neuronal function in human organoidsSemantic proximity Read