Article

Transcriptome Analysis of Brain Tissues in a MeCP2-Null Rat Model of Rett Syndrome

2019-04-02

Abstract excerpt

<h4>Objective: </h4> Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in MeCP2, a transcription factor. MeCP2 mutations cause abnormal expression of downstream genes and eventually lead to brain dysfunction. The role of MeCP2 in brain neural development remains unclear. To further elucidate this role, a MeCP2-null rat model was created with the CRISPR/cas9 system. <h4>Method:</h4>...

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Literature Corpus work: 889bcc24-3fa1-5ad3-b7be-bc5de6308b0d
DOI: 10.20944/preprints201904.0031.v1

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