Article

Molecular and Functional Dysregulations in Novel, Rett Syndrome Patient-Derived Cerebral Organoids

2026-07-08

Abstract excerpt

<title>Abstract</title> <p> Rett syndrome (RTT) is a severe neurodevelopmental disorder (NDD) caused by mutations in <italic>MECP2</italic> . Although existing RTT organoid models recapitulate key disease-associated phenotypes, scalable and patient-relevant platforms for mechanistic and therapeutic studies remain limited. Here, we establish clonal cerebral organoids (COs) derived from patient neural stem cells...

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Literature Corpus work: 8c309800-234b-53de-a564-d9d090ec3882
DOI: 10.21203/rs.3.rs-10208343/v1

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