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Article

Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids.

Nature communications - 14 Apr 2026

Osaki Tatsuya, Delepine Chloe, Osako Yuma, Kranz Devorah, Levin April, Nelson Charles, Fagiolini Michela, Sur Mriganka

Abstract excerpt

Human cerebral organoids derived from induced pluripotent stem cells can recapture early developmental processes and reveal changes involving neurodevelopmental disorders. Mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene are associated with Rett syndrome, and disease severity varies depending on the location and type of mutation. Here, we focused on neuronal activity in Rett syndrome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyl-CpG-Binding Protein 2

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Source

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Identifiers

PMID: 41980938
DOI: 10.1038/s41467-026-71458-0
PMCID: PMC13260836

Genes

MECP2
HDAC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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