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Article

Involvement of extracellular vesicle microRNA clusters in developing healthy and Rett syndrome brain organoids.

Cellular and molecular life sciences : CMLS - 21 Sept 2024

Bahram Sangani Nasim, Koetsier Jarno, Gomes Ana Rita, Diogo Maria Margarida, Fernandes Tiago G, Bouwman Freek G, Mariman Edwin C M, Ghazvini Mehrnaz, Gribnau Joost, Curfs Leopold M G, Reutelingsperger Chris P, Eijssen Lars M T

Abstract excerpt

Rett syndrome (RTT) is a neurodevelopmental disorder caused by de novo mutations in the MECP2 gene. Although miRNAs in extracellular vesicles (EVs) have been suggested to play an essential role in several neurological conditions, no prior study has utilized brain organoids to profile EV-derived miRNAs during normal and RTT-affected neuronal development. Here we report the spatiotemporal expression pattern of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39305343
DOI: 10.1007/s00018-024-05409-7
PMCID: PMC11416455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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