Article
MECP2T203M mutation disrupts neurogenesis in human cerebral organoids by altering chromatin dynamics and transcriptional regulation.
Science China. Life sciences - 1 Aug 2026
Song Zhihong, Zhu Qian, Yang Rui, Jiang Huihui, Li Ying, Chen Liping, Wang Ting, Wu Yan, Liu Yan, Wu Haitao
Abstract excerpt
Rett syndrome (RTT) is a severe, neurodevelopmental disorder caused primarily by loss-of-function mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Although the regulatory role of MECP2 in neuronal development and postnatal functions has been thoroughly investigated, its mechanisms in prenatal human brain development remain elusive. Here, we successfully established a stable culture of cerebral...
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