Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MeCP2 dysregulation inhibits mitophagy and impairs neural development in cortical organoids.

Journal of advanced research - 1 Apr 2026

Zhou Jing, Liu Yuchun, Jing Xintao, Peng Hang, Li Fang, Cao Li, Li Wen, Li Rufeng, Zhang Jinyuan, Wang Xiaofei, Lian Jiangfang, Tong Dongdong, Huang Chen

Abstract excerpt

INTRODUCTION: Methylated CpG-binding protein 2 (MeCP2) plays a critical role in the normal development and function of the nervous system. Mutations in MeCP2 have been linked to neurodevelopmental disorders, potentially because of mitochondrial dysfunction and impaired mitophagy. However, the underlying mechanisms remain poorly understood. Investigating the role of MeCP2 in the regulation of mitophagy is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebral Cortex
Share to Induced Pluripotent Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyl-CpG-Binding Protein 2

Share to Mitochondria

Share to Mitophagy

Share to Neural Stem Cells

Share to Neurogenesis

Share to Organoids

Source

Open in PubMed Open full text

Identifiers

PMID: 40691988
DOI: 10.1016/j.jare.2025.07.035
PMCID: PMC13001064

Genes

BNIP3L

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MeCP2 dysregulation inhibits mitophagy and impairs neural development in cortical organoids.PMID 40691988Read ↗

Multi-omics profiling reveals MAGEL2-driven defects in human corticogenesis shared across Prader-Willi and Schaaf-Yang syndromesSemantic proximity Read ↗

MECP2T203M mutation disrupts neurogenesis in human cerebral organoids by altering chromatin dynamics and transcriptional regulation.Semantic proximity Read ↗

Hallmark molecular and pathological features of POLG disease are recapitulated in cerebral organoidsSemantic proximity Read ↗

Cortical Organoids Model Early Brain Development Disrupted by 16p11.2 Copy Number Variants in AutismSemantic proximity Read ↗

KW-2449 and VPA exert therapeutic effects on human neurons and cerebral organoids derived from MECP2-null hESCsSemantic proximity Read ↗

MECP2 and the biology of MECP2 duplication syndrome.Semantic proximity Read ↗

Loss of <i>UBE3A</i> impacts both neuronal and non-neuronal cells in human cerebral organoidsSemantic proximity Read ↗

GABA/Glutamate neuron differentiation imbalance and increased AKT/mTOR signalling in CNTNAP2 <sup>-/-</sup> cerebral organoidsSemantic proximity Read ↗

Molecular and Functional Dysregulations in Novel, Rett Syndrome Patient-Derived Cerebral OrganoidsSemantic proximity Read ↗

Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.Semantic proximity Read ↗

Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids.Semantic proximity Read ↗

Longitudinal multi-omics reveals pathogenic <i>TSC2</i> variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis ComplexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.