Article

Overexpression of the schizophrenia risk gene C4 in PV cells drives sex-dependent behavioral deficits and circuit dysfunction

2024-01-28

Abstract excerpt

<h4>SUMMARY</h4> Fast-spiking parvalbumin (PV)-positive cells are key players in orchestrating pyramidal neuron activity, and their dysfunction is consistently observed in myriad brain diseases. To understand how immune complement dysregulation – a prevalent locus of brain disease etiology – in PV cells may drive disease pathogenesis, we have developed a transgenic mouse line that permits cell-type specific overe...

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Literature Corpus work: b794696a-9c5f-55ef-b41c-c9a8d34ea70d
DOI: 10.1101/2024.01.27.575409

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