Article

<i>Erbb4</i> deletion from fast-spiking interneurons causes psychosis-relevant neuroimaging phenotypes

2022-03-08

Abstract excerpt

Converging lines of evidence suggest that dysfunction of cortical parvalbumin-expressing (PV+) GABAergic interneurons is a core feature of psychosis. This dysfunction is thought to underlie neuroimaging abnormalities commonly found in patients with psychosis, particularly in the hippocampus. These include increases in resting cerebral blood flow (CBF) and levels of glutamatergic metabolites, and decreases in bindi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 013000cd-0eba-5c70-879c-de394e0ce805
DOI: 10.1101/2022.03.07.483347

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Erbb4</i> deletion from fast-spiking interneurons causes psychosis-relevant neuroimaging phenotypesDOI 10.1101/2022.03.07.483347Read

Erbb4 Deletion From Inhibitory Interneurons Causes Psychosis-Relevant Neuroimaging Phenotypes.Semantic proximity Read

Genetic association of ErbB4 and human cortical GABA levels in vivo.Semantic proximity Read

Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes.Semantic proximity Read

Genetic deletion of fibroblast growth factor 14 recapitulates phenotypic alterations underlying cognitive impairment associated with schizophrenia.Semantic proximity Read

Prefrontal cognitive deficits in mice with altered cerebral cortical GABAergic interneurons.Semantic proximity Read

Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia ModelSemantic proximity Read

Discovering functional interactions among schizophrenia-risk genes by combining behavioral genetics with cell biology.Semantic proximity Read

Overexpression of the schizophrenia risk gene C4 in PV cells drives sex-dependent behavioral deficits and circuit dysfunctionSemantic proximity Read

Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk.Semantic proximity Read

The transcriptional landscape of cortical interneurons underlies <i>in-vivo</i> brain function and schizophrenia riskSemantic proximity Read

<i>Grin2a</i> Ablation Distinctly Reshapes PV+ and SST+ Interneuron circuits in the Medial Prefrontal Cortex to Amplify Gamma OscillationsSemantic proximity Read

The Nature of Prefrontal Cortical GABA Neuron Alterations in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene Expression Without Missing NeuronsSemantic proximity Read