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Article

Genetic deletion of fibroblast growth factor 14 recapitulates phenotypic alterations underlying cognitive impairment associated with schizophrenia.

Translational psychiatry - 10 May 2016

Alshammari T K, Alshammari M A, Nenov M N, Hoxha E, Cambiaghi M, Marcinno A, James T F, Singh P, Labate D, Li J, Meltzer H Y, Sacchetti B, Tempia F, Laezza F

Abstract excerpt

Cognitive processing is highly dependent on the functional integrity of gamma-amino-butyric acid (GABA) interneurons in the brain. These cells regulate excitability and synaptic plasticity of principal neurons balancing the excitatory/inhibitory tone of cortical networks. Reduced function of parvalbumin (PV) interneurons and disruption of GABAergic synapses in the cortical circuitry result in desynchronized...

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Source

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Identifiers

PMID: 27163207
DOI: 10.1038/tp.2016.66
PMCID: PMC5070049

Genes

FGF14
PVALB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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